Dear Writer, I'm sorry to hear about your mom who must be in a lot of discomfort. Are the blisters appearing mostly on the abdomen, arms, and legs? Does she also have blisters in mouth? Was she diagnosed with bullous pemphigoid? Often blisters are fluid-filled, and sometimes there is intense itching as well. Western medicine considers this to be a malfuntion of the immune system, while Ayurveda's perspective is that there is accumulation of aama (toxins) that are erupting through the skin. Thus we work on purifying the blood which results in the skin returning back to normal, and permanently, as long as the person adheres to certain dietary guidelines (so aama doesn't accumulate again). Medicinal herbs such as neem and manjistha are very effective when taken in a formula with supporting herbs. Prednisone is just a temporary band-aid and is a risky approach for long term treatment. I'm happy to help your Mom in whatever way I can to relieve her discomfort.